{"product_id":"cleaved-caspase-4-5-p20-d270-d311-polyclonal-antibody-ra23462","title":"Cleaved-Caspase-4\/5 p20 (D270\/D311) Polyclonal Antibody - RA23462","description":"\u003cp\u003eCleaved-Caspase-4\/5 p20 (D270\/D311) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA23462-50, RA23462-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: caspase 4 (CASP4) Homo sapiens This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: CASP4; ICH2; Caspase-4; CASP-4; ICE (rel) -II; Protease ICH-2; Protease TX; CASP5; ICH3; Caspase-5; CASP-5; ICE (rel) -III; Protease ICH-3; Protease TY\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 837\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 47,22\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P49662\/P51878\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121204650163,"sku":"RA23462-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121204682931,"sku":"RA23462-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_6eec642a-00f5-4bfa-bb0e-877f917b1367.png?v=1773345201","url":"https:\/\/afsbio.com\/products\/cleaved-caspase-4-5-p20-d270-d311-polyclonal-antibody-ra23462","provider":"AFSBio Inc.","version":"1.0","type":"link"}