{"product_id":"cleaved-caspase-4-5-p20-polyclonal-antibody-bz16485","title":"Cleaved-Caspase 4\/5 p20 Polyclonal Antibody-BZ16485","description":"\u003cp\u003eCleaved-Caspase 4\/5 p20 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BZ16485-50, BZ16485-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P49662\/P51878\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB,ELISA\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000  ELISA: 1\/10000\u003c\/p\u003e\n\n\u003cp\u003eBackground: CASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Cleaved-Caspase 4\/5 p20 in JurkatLysates using Caspase 4\/5 antibody. The lane on the right is blocked with the Caspase 4\/5 peptide.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 43 kDa; Observed MW: 47,22 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: TX; Mih1; ICH-2; Mih1\/TX; ICEREL-II; ICE(rel)II\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Caspase 4\/5. AA range:221-270\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Cleaved\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42932550959283,"sku":"BZ16485-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42932550992051,"sku":"BZ16485-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e10593a9-c705-4f83-8794-296affc08d60.jpg?v=1704284865","url":"https:\/\/afsbio.com\/products\/cleaved-caspase-4-5-p20-polyclonal-antibody-bz16485","provider":"AFSBio Inc.","version":"1.0","type":"link"}