{"product_id":"cleaved-cathepsin-l1-hc-t288-polyclonal-antibody-bt-ap01912","title":"Cleaved-Cathepsin L1 HC (T288) Polyclonal Antibody - BT-AP01912","description":"\u003cp\u003eCleaved-Cathepsin L1 HC (T288) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01912-20, BT-AP01912-50, BT-AP01912-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by CTSL is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein (cathepsin L) has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. cathepsin L, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for CTSL.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CTSL1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Cleaved-Cathepsin L1 HC (T288) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 37564\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P07711; Mouse: P06797\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CTSL1; CTSL; Cathepsin L1; Major excreted protein; MEP\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1514\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240208064691,"sku":"BT-AP01912-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240208097459,"sku":"BT-AP01912-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240208130227,"sku":"BT-AP01912-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_dc4591df-7b73-46d6-8c50-a5b3245b94af.png?v=1769405128","url":"https:\/\/afsbio.com\/products\/cleaved-cathepsin-l1-hc-t288-polyclonal-antibody-bt-ap01912","provider":"AFSBio Inc.","version":"1.0","type":"link"}