{"product_id":"cleaved-factor-vii-lc-r212-polyclonal-antibody-bt-ap01922","title":"Cleaved-Factor VII LC (R212) Polyclonal Antibody - BT-AP01922","description":"\u003cp\u003eCleaved-Factor VII LC (R212) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01922-20, BT-AP01922-50, BT-AP01922-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: F7 encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and\/or factor X to factor Xa. Defects in F7 can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: F7\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Cleaved-Factor VII LC (R212) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 51594\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P08709; Mouse: P70375\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: F7; Coagulation factor VII; Proconvertin; Serum prothrombin conversion accelerator; SPCA; Eptacog alfa\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2155\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240209080499,"sku":"BT-AP01922-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240209113267,"sku":"BT-AP01922-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240209146035,"sku":"BT-AP01922-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_10f88d8d-b328-43f4-b556-012de504b52e.png?v=1769405143","url":"https:\/\/afsbio.com\/products\/cleaved-factor-vii-lc-r212-polyclonal-antibody-bt-ap01922","provider":"AFSBio Inc.","version":"1.0","type":"link"}