{"product_id":"cleaved-factor-x-factor-x-lc-a41-polyclonal-antibody-bt-ap01923","title":"Cleaved-Factor X\/ Factor X LC (A41) Polyclonal Antibody - BT-AP01923","description":"\u003cp\u003eCleaved-Factor X\/ Factor X LC (A41) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01923-20, BT-AP01923-50, BT-AP01923-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: F10 encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: F10\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Cleaved-Factor X\/ Factor X LC (A41) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 54732\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P00742; Mouse: O88947\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: F10; Coagulation factor X; Stuart factor; Stuart-Prower factor\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2159\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240209178803,"sku":"BT-AP01923-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240209211571,"sku":"BT-AP01923-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240209244339,"sku":"BT-AP01923-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_53a80862-82a5-4c5e-99fe-9148d0008ad5.png?v=1769405145","url":"https:\/\/afsbio.com\/products\/cleaved-factor-x-factor-x-lc-a41-polyclonal-antibody-bt-ap01923","provider":"AFSBio Inc.","version":"1.0","type":"link"}