{"product_id":"cleaved-integrin-α6-lc-e942-rabbit-pab-es1063","title":"Cleaved-Integrin α6 LC (E942) rabbit pAb - ES1063","description":"\u003cp\u003eCleaved-Integrin α6 LC (E942) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1063-50, ES1063-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: integrin subunit alpha 6 (ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2\/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human ITGA6. AA range:923-972\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 28kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 3655\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P23229\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201999888563,"sku":"ES1063-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201999921331,"sku":"ES1063-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_bbfa4cdc-3c26-489f-9554-b82e3a60808a.png?v=1767119657","url":"https:\/\/afsbio.com\/products\/cleaved-integrin-%ce%b16-lc-e942-rabbit-pab-es1063","provider":"AFSBio Inc.","version":"1.0","type":"link"}