{"product_id":"cleaved-lamin-a-d230-polyclonal-antibody-bt-ap01940","title":"Cleaved-Lamin A (D230) Polyclonal Antibody - BT-AP01940","description":"\u003cp\u003eCleaved-Lamin A (D230) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01940-20, BT-AP01940-50, BT-AP01940-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in LMNA lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: LMNA\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Cleaved-Lamin A (D230) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 74139\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P02545; Mouse: P48678; Rat: P48679\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: LMNA; LMN1; Prelamin-A\/C\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4000; Mouse: 16905; Rat: 60374\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240210948275,"sku":"BT-AP01940-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240210981043,"sku":"BT-AP01940-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240211013811,"sku":"BT-AP01940-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_031ccadb-64fb-4677-aaf7-3e4c47d2dd27.png?v=1769405171","url":"https:\/\/afsbio.com\/products\/cleaved-lamin-a-d230-polyclonal-antibody-bt-ap01940","provider":"AFSBio Inc.","version":"1.0","type":"link"}