{"product_id":"cleaved-notch-1-v1754-polyclonal-antibody-bs7018","title":"Cleaved-Notch 1 (V1754) Polyclonal Antibody - BS7018","description":"\u003cp\u003eCleaved-Notch 1 (V1754) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7018-50, BS7018-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Notch1 is a transmembrane protein functioning in development and the determination of cell fate. During maturation, the notch molecμle is cleaved by a furin-like convertase at its extracellμlar domain. Upon binding to a ligand such as Delta1, or upon extracellμlar calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1753 and Val1754. The resμlting activated cytosolic fragment translocates to the nucleus where it activates transcription.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Neurogenic locus notch homolog protein 1, Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 intracellμlar domain, NICD, NOTCH1, TAN1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Cleaved\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 1700-1800 of Human Notch 1.\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Cleaved-Notch 1 (V1754) polyclonal antibody detects endogenous levels of the Notch1 intracellμlar domain (NICD) . The antibody does not recognize fμll-length Notch1.\u003c\/p\u003e \n\n\u003cp\u003eMolecular Weight: ~ 110 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Neuronal and Glial Cell Marker Atlas, Notch Signaling, Tumor Angiogenesis, Contribution of Soluble Factors to EMT,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P46531\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946378518707,"sku":"BS7018-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946378551475,"sku":"BS7018-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/cleaved-notch-1-v1754-polyclonal-antibody-bs7018","provider":"AFSBio Inc.","version":"1.0","type":"link"}