{"product_id":"cleaved-parp-mouse-monoclonal-antibody-em1132","title":"Cleaved PARP Mouse Monoclonal Antibody - EM1132","description":"\u003cp\u003eCleaved PARP Mouse Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: EM1132-50, EM1132-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PARP-1, Poly(ADP ribose) polymerase 1, sPARP1, ADPRT1, ADP ribosyltransferase NAD(+)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG1\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1, 000-3, 000   IHC 1:200-500\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 116, 89kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 142\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: P09874\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825534263475,"sku":"EM1132-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825534296243,"sku":"EM1132-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/cleaved-parp-mouse-monoclonal-antibody-em1132","provider":"AFSBio Inc.","version":"1.0","type":"link"}