{"product_id":"cln6-n258-polyclonal-antibody-bs3102","title":"CLN6 (N258) Polyclonal Antibody-BS3102","description":"\u003cp\u003eCLN6 (N258) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3102-50, BS3102-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9NWW5\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e \n\n\u003cp\u003eBackground: CLN6, a 311-amino acid protein, has 7 predicted transmembrane domains and is conserved across vertebrates. The CLN6 protein localizes to the endoplasmic reticulum but contributes to lysosomal function. Mutations in the CLN6 gene cause variant late-onset infantile neuronal ceroid lipofuscinosis (vLINCL), a lysosomal storage disorder marked by progressive mental deterioration and blindness; part of a group of severe inherited neurodegenerative disorders affecting children wherein lysosomes accumulate storage material, causing the death of neurons. CLN6 is one of eight proteins, including CLN1-8, that are associated with NCL.\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CLN6 (N258) polyclonal antibody detects endogenous levels of CLN6 protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of CLN6 (N258) pAb at 1:500 dilution\u003cbr\u003e\nLane 1: SGC7901 whole cell lysate (40ug)\u003cbr\u003e\nLane 2: SK-OVCAR3 whole cell lysate (40ug)\u003cbr\u003e\nLane 3: MCF-7 whole cell lysate (40ug)\u003cbr\u003e\nLane 4: PC12 whole cell lysate (40ug)\u003cbr\u003e\nLane 5: CT26 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of CLN6 (N258) pAb in paraffin-embedded human stomach carcinoma tissue at 1:50.showing nuclear and strong cytoplasmic staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 40 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Ceroid-lipofuscinosis neuronal protein 6; Protein CLN6; CLN6\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 229-274 of Human CLN6.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953232613555,"sku":"BS3102-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953232646323,"sku":"BS3102-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_202c072e-0114-4355-b4d2-404a1cbbc1bd.jpg?v=1705057316","url":"https:\/\/afsbio.com\/products\/cln6-n258-polyclonal-antibody-bs3102","provider":"AFSBio Inc.","version":"1.0","type":"link"}