{"product_id":"clus-rabbit-polyclonal-antibody-es8926","title":"CLUS Rabbit Polyclonal Antibody - ES8926","description":"\u003cp\u003eCLUS Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8926-50, ES8926-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1\/NA2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain), Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain)]\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human CLUS Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: CLUS\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of CLUS.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, ELISA 1:10000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa, Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level), Ubiquitous, Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 52kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Complement and coagulation cascades\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Not yet clear. It is known to be expressed in a variety of tissues and it seems to be able to bind to cells, membranes and hydrophobic proteins. It has been associated with programmed cell death (apoptosis)\u003cbr\u003e\nSimilarity: Belongs to the clusterin family\u003cbr\u003e\nSubunit: Antiparallel disulfide-linked heterodimer. Interacts with APOA1, CLUAP1 AND PON1\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: [Isoform 1]: Secreted Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress, [Isoform 4]: Cytoplasm Keeps cytoplasmic localization in stressed and unstressed cell, [Isoform 6]: Cytoplasm Keeps cytoplasmic localization in stressed and unstressed cell, Nucleus Cytoplasm Mitochondrion membrane, Peripheral membrane protein, Cytoplasmic side Cytoplasm, cytosol Microsome Endoplasmic reticulum Mitochondrion Mitochondrion membrane Cytoplasm, perinuclear region Cytoplasmic vesicle, secretory vesicle, chromaffin granule Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress (PubMed:17451556) Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CLU APOJ CLI KUB1 AAG4\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1\/NA2) (Testosterone-\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 12759\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q06890\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 24854\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P05371\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313944154291,"sku":"ES8926-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313944187059,"sku":"ES8926-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/clus-rabbit-polyclonal-antibody-es8926","provider":"AFSBio Inc.","version":"1.0","type":"link"}