{"product_id":"clusterin-rabbit-pab-es2006","title":"Clusterin rabbit pAb - ES2006","description":"\u003cp\u003eClusterin rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2006-50, ES2006-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: CLU; APOJ; CLI; KUB1; AAG4; Clusterin; Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40; 40; Ku70-binding protein 1; NA1\/NA2; Testosterone-repressed prostate m\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human CLU. AA range:400-449\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 52kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 1191\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P10909\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Isoform 1]: Secreted. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.; [Isoform 4]: Cytoplasm. Keeps cytoplasmic localization in stressed and unstressed cell.; [Isoform 6]: Cytoplasm. Keeps cytoplasmic localization in stressed and unstressed cell.; Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Mitochondrion. Mitochondrion membrane. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress (PubMed:17451556). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202049007795,"sku":"ES2006-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202049040563,"sku":"ES2006-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_cdfc0fc9-47b3-4728-9c27-ffb09b9556a5.png?v=1767120686","url":"https:\/\/afsbio.com\/products\/clusterin-rabbit-pab-es2006","provider":"AFSBio Inc.","version":"1.0","type":"link"}