{"product_id":"cmip-rabbit-polyclonal-antibody-es17366","title":"CMIP Rabbit Polyclonal Antibody - ES17366","description":"\u003cp\u003eCMIP Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES17366-50, ES17366-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human CMIP AA range: 105-155\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: CMIP\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of CMIP at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.345% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney, Lower expression in brain and liver, Expression is down-regulated in activated cells, Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 85kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Developmental Stage: Expressed in fetal liver\u003cbr\u003e\nDisease: Isoform 2 expression is up-regulated in MCNS\u003cbr\u003e\nFunction: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor\u003cbr\u003e\nSimilarity: Contains 1 PH domain\u003cbr\u003e\nSubcellular Location: Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients\u003cbr\u003e\nSubunit: Interacts with FLNA\u003cbr\u003e\nTissue Specificity: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Is\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus Cytoplasm Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553) Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553) Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CMIP KIAA1694 TCMIP\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: CMIP\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 74440\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9D486\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315569938611,"sku":"ES17366-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315569971379,"sku":"ES17366-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/cmip-rabbit-polyclonal-antibody-es17366","provider":"AFSBio Inc.","version":"1.0","type":"link"}