{"product_id":"co3-polyclonal-antibody-bt-ap07921","title":"CO3 Polyclonal Antibody - BT-AP07921","description":"\u003cp\u003eCO3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP07921-20, BT-AP07921-50, BT-AP07921-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Immunology; Neuroscience; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: C3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Complement C3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P01024; Mouse: P01027; Rat: P01026\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Complement C3;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein;\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 718\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239100375219,"sku":"BT-AP07921-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239100407987,"sku":"BT-AP07921-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239100440755,"sku":"BT-AP07921-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_22be3f3e-b806-4fc9-97f6-1eb0fa54bd67.png?v=1769389117","url":"https:\/\/afsbio.com\/products\/co3-polyclonal-antibody-bt-ap07921","provider":"AFSBio Inc.","version":"1.0","type":"link"}