{"product_id":"co8g-rabbit-polyclonal-antibody-es11965","title":"CO8G Rabbit Polyclonal Antibody - ES11965","description":"\u003cp\u003eCO8G Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES11965-50, ES11965-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: CO8G\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CO8G Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Blood, Colon, Liver,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 22kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Complement and coagulation cascades, Prion disease, Amoebiasis, Coronavirus disease - COVID-19, Systemic lupus erythematosus\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol\u003cbr\u003e\nSimilarity: Belongs to the calycin superfamily. Lipocalin family\u003cbr\u003e\nSubunit: C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Secreted\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: C8G\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Complement component C8 gamma chain\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8VCG4\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314538369203,"sku":"ES11965-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314538401971,"sku":"ES11965-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/co8g-rabbit-polyclonal-antibody-es11965","provider":"AFSBio Inc.","version":"1.0","type":"link"}