{"product_id":"col18a1-polyclonal-antibody-bt-ap02071","title":"COL18A1 Polyclonal Antibody - BT-AP02071","description":"\u003cp\u003eCOL18A1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02071-20, BT-AP02071-50, BT-AP02071-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: COL18A1 (collagen type XVIII alpha 1 chain) encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in COL18A1 are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: COL18A1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: COL18A1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 178160\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P39060; Mouse: P39061\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: COL18A1; Collagen alpha-1(XVIII) chain\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 80781; Mouse: 12822\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240222875827,"sku":"BT-AP02071-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240222908595,"sku":"BT-AP02071-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240222941363,"sku":"BT-AP02071-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_bb76f71a-43d8-45d1-a231-aa46a4844dca.png?v=1769405320","url":"https:\/\/afsbio.com\/products\/col18a1-polyclonal-antibody-bt-ap02071","provider":"AFSBio Inc.","version":"1.0","type":"link"}