{"product_id":"col25a1-polyclonal-antibody-ra23637","title":"COL25A1 Polyclonal Antibody - RA23637","description":"\u003cp\u003eCOL25A1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA23637-50, RA23637-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: collagen type XXV alpha 1 chain (COL25A1) Homo sapiens This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410) . A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: COL25A1; Collagen alpha-1 (XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC-p; IF\/ICC; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 84570\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 64\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9BXS0\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121213530291,"sku":"RA23637-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121213563059,"sku":"RA23637-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c42392f8-9bbe-42af-bca2-80c5d53c7937.png?v=1773345303","url":"https:\/\/afsbio.com\/products\/col25a1-polyclonal-antibody-ra23637","provider":"AFSBio Inc.","version":"1.0","type":"link"}