{"product_id":"collagen-i-col1a1-rabbit-polymab®-a24112pm","title":"Collagen I\/COL1A1 Rabbit PolymAb® - A24112PM","description":"\u003cp\u003eCollagen I\/COL1A1 Rabbit PolymAb®\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A24112PM-20, A24112PM-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF\/ICC, IF-F, IF-P, IHC-P, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 139kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 220kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 1277\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P02452\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: OI1; OI2; OI3; OI4; EDSC; CAFYD; EDSARTH1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS with 0.09% sodium azide, 0.05% BSA, 50% glycerol, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:6000 - 1:36000 IF\/ICC, 1:200 - 1:2000 IF-F, 1:200 - 1:2000 IF-P, 1:200 - 1:2000 IHC-P, 1:2000 - 1:8000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction； Cytoskeleton \/ ECM ；Extracellular Matrix ；ECM Proteins ；Collagen；Stem Cells ；Mesenchymal Stem Cells ；Osteogenesis.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: COL1A1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189848301747,"sku":"A24112PM-20","price":165.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189848334515,"sku":"A24112PM-100","price":431.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_b76dceec-d9d3-4ee5-94c5-cc90ddc4b623.png?v=1766436695","url":"https:\/\/afsbio.com\/products\/collagen-i-col1a1-rabbit-polymab%c2%ae-a24112pm","provider":"AFSBio Inc.","version":"1.0","type":"link"}