{"product_id":"collagen-iv-mouse-monoclonal-antibody-8e5-bt-mca0363","title":"Collagen IV mouse Monoclonal Antibody (8E5) - BT-MCA0363","description":"\u003cp\u003eCollagen IV mouse Monoclonal Antibody (8E5)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-MCA0363-20, BT-MCA0363-50, BT-MCA0363-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Stem cells; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: COL4A1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, ICC, IHC-p\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Mouse,Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Collagen alpha-1(IV) chain\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: p02462; Mouse: P02463\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Collagen alpha-1(IV) chain\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1282\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240035049651,"sku":"BT-MCA0363-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240035082419,"sku":"BT-MCA0363-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240035115187,"sku":"BT-MCA0363-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_2dd48a45-d164-4eed-b6bb-baef5ae1678c.png?v=1769402462","url":"https:\/\/afsbio.com\/products\/collagen-iv-mouse-monoclonal-antibody-8e5-bt-mca0363","provider":"AFSBio Inc.","version":"1.0","type":"link"}