{"product_id":"collagen-iv-mouse-monoclonal-antibody-8g3-ra10563","title":"Collagen IV Mouse Monoclonal Antibody (8G3) - RA10563","description":"\u003cp\u003eCollagen IV Mouse Monoclonal Antibody (8G3)\u003c\/p\u003e \n\n\u003cp\u003eSize: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA10563-50, RA10563-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: collagen type IV alpha 1 chain (COL4A1) Homo sapiens This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p; IF (paraffin section)\u003c\/p\u003e \n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 1282\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 161\u003c\/p\u003e\n\n\u003cp\u003eSWISS: p02462\u003c\/p\u003e\n\n\u003cp\u003eSource: Mouse\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119014928563,"sku":"RA10563-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119014961331,"sku":"RA10563-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f2922c71-7332-4eb2-89e0-a73a32e1c07e.png?v=1773344284","url":"https:\/\/afsbio.com\/products\/collagen-iv-mouse-monoclonal-antibody-8g3-ra10563","provider":"AFSBio Inc.","version":"1.0","type":"link"}