{"product_id":"comp-rabbit-polyclonal-antibody-es17302","title":"COMP Rabbit Polyclonal Antibody - ES17302","description":"\u003cp\u003eCOMP Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES17302-50, ES17302-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human COMP AA range: 628-678\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: COMP\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of COMP at Human\/Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels, Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 83kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Phagosome, PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Malaria, Human papillomavirus infection\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in COMP are the cause of multiple epiphyseal dysplasia type 1 (EDM1) [MIM: 132400]. EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types\u003cbr\u003e\nDisease: Defects in COMP are the cause of pseudoachondroplasia (PSACH) [MIM: 177170]. PSAC is a dominantly inherited chondrodysplasia characterized by short stature and early-onset osteoarthrosis. PSACH is more severe than EDM1 and is recognized in early childhood\u003cbr\u003e\nSimilarity: Belongs to the thrombospondin family\u003cbr\u003e\nSimilarity: Contains 1 TSP C-terminal (TSPC) domain\u003cbr\u003e\nSimilarity: Contains 4 EGF-like domains\u003cbr\u003e\nSimilarity: Contains 8 TSP type-3 repeats\u003cbr\u003e\nSubunit: Pentamer, disulfide-linked\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Secreted, extracellular space, extracellular matrix\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: COMP\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: COMP\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 12845\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9R0G6\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 25304\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P35444\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315560239283,"sku":"ES17302-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315560272051,"sku":"ES17302-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/comp-rabbit-polyclonal-antibody-es17302","provider":"AFSBio Inc.","version":"1.0","type":"link"}