{"product_id":"comt-polyclonal-antibody-bs90320","title":"COMT Polyclonal Antibody-BS90320","description":"\u003cp\u003eCOMT Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90320-50, BS90320-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P21964(Human) O88587(Mouse) P22734(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500-1:2,000\u003cbr\u003e\nIHC:1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: Catechol-O-methyltransferase (COMT) plays a crucial role in the regulation of central dopaminergic systems by catalyzing the inactivation of catechol-amines. It is widely distributed in most tissues in soluble and membrane-bound forms. COMT-mediated methylation metabolism of catecholamine neurotransmitters is a first-line detoxification pathway. A Val158Met polymorphism of the COMT gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex of the brain. Sequential conversion of estradiol to methoxyestradiol by COMT, contributes to the antimitogenic effects of estradiol on vascular smooth muscle cell growth via estrogen receptor-independent mechanisms.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: COMT polyclonal antibody detects endogenous levels of COMT protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 24 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of COMT on MCF-7 cell (1) and rat testis tissue (2) lysate using anti-COMT antibody at 1\/2,000 dilution., Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-COMT antibody. Counter stained with hematoxylin.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: COMT, Catechol O methyltransferase, Catechol O-methyltransferase, COMT, COMT, EC 2.1.1.6,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant protein of C-terminal human COMT.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42979800907955,"sku":"BS90320-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42979800940723,"sku":"BS90320-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_baa8bae3-7fbd-4235-8c13-9d4c38c53c32.jpg?v=1705752819","url":"https:\/\/afsbio.com\/products\/comt-polyclonal-antibody-bs90320","provider":"AFSBio Inc.","version":"1.0","type":"link"}