{"product_id":"cops5-jab1-k191-polyclonal-antibody-bs2340","title":"COPS5 \/ JAB1 (K191) Polyclonal Antibody-BS2340","description":"\u003cp\u003eCOPS5 \/ JAB1 (K191) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2340-50, BS2340-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q92905\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e \n\n\u003cp\u003eBackground: Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos\/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Junactivation\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: JAB1 (K191) polyclonal antibody detects endogenous levels of JAB1 protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of COPS5\/JAB1 (K191) pAb at 1:1000 dilution\u003cbr\u003e\nLane 1: A549 whole cell lysate (40ug)\u003cbr\u003e\nLane 2: MCF-7 whole cell lysate (40ug)\u003cbr\u003e\nLane 3: The Lung tissue lysate of Rat (40ug)\u003cbr\u003e\nLane 4: CT26 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of COPS5 \/ JAB1 (K191) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 38 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; Jun activation domain-binding protein; COPS5; CSN5; JAB1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 160-212 of Human COPS5 \/ JAB1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953224126643,"sku":"BS2340-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953224159411,"sku":"BS2340-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_7eedc8aa-75a2-44ca-9bc4-f1b9a85f9bf8.jpg?v=1705057117","url":"https:\/\/afsbio.com\/products\/cops5-jab1-k191-polyclonal-antibody-bs2340","provider":"AFSBio Inc.","version":"1.0","type":"link"}