{"product_id":"cortactin-polyclonal-antibody-bt-ap02138","title":"Cortactin Polyclonal Antibody - BT-AP02138","description":"\u003cp\u003eCortactin Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02138-20, BT-AP02138-50, BT-AP02138-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F-actin and Arp2\/3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin exist due to the alternative splicing.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CTTN\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Cortactin Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 61636\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q14247; Mouse: Q60598\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 13043; Mouse: 13043\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240228642995,"sku":"BT-AP02138-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240228675763,"sku":"BT-AP02138-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240228708531,"sku":"BT-AP02138-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_144a82a6-c7e5-4ff8-8c7c-261d289e5550.png?v=1769405401","url":"https:\/\/afsbio.com\/products\/cortactin-polyclonal-antibody-bt-ap02138","provider":"AFSBio Inc.","version":"1.0","type":"link"}