{"product_id":"corticotropin-releasing-factor-receptor-2-rabbit-polyclonal-antibody-es8600","title":"Corticotropin-releasing factor receptor 2 Rabbit Polyclonal Antibody - ES8600","description":"\u003cp\u003eCorticotropin-releasing factor receptor 2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8600-50, ES8600-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide from human protein at AA range: 221-295\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: CRF-RII\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: The antibody detects endogenous Corticotropin-releasing factor receptor 2\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, ELISA 1:10000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Amygdala, Brain, Skeletal muscle,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 48kD\u003c\/p\u003e\n\n\u003cp\u003eFields: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Cushing syndrome\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase\u003cbr\u003e\nSimilarity: Belongs to the G-protein coupled receptor 2 family\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CRHR2 CRF2R CRH2R\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Corticotropin-releasing factor receptor 2\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q60748\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P47866\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313851224243,"sku":"ES8600-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313851257011,"sku":"ES8600-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/corticotropin-releasing-factor-receptor-2-rabbit-polyclonal-antibody-es8600","provider":"AFSBio Inc.","version":"1.0","type":"link"}