{"product_id":"cot-polyclonal-antibody-bt-ap02143","title":"Cot Polyclonal Antibody - BT-AP02143","description":"\u003cp\u003eCot Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02143-20, BT-AP02143-50, BT-AP02143-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: MAP3K8 is an oncogene that encodes a member of the serine\/threonine protein kinase family. The mitogen-activated protein kinase kinase kinase 8 localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. MAP3K8 may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MAP3K8\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Cot Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 52925\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P41279; Mouse: Q07174; Rat: Q63562\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: MAP3K8; COT; ESTF; Mitogen-activated protein kinase kinase kinase 8; Cancer Osaka thyroid oncogene; Proto-oncogene c-Cot; Serine\/threonine-protein kinase cot; Tumor progression locus 2; TPL-2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1326; Mouse: 26410; Rat: 116596\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240229036211,"sku":"BT-AP02143-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240229068979,"sku":"BT-AP02143-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240229101747,"sku":"BT-AP02143-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_532cc823-1bfc-4c01-872b-d01aba99742b.png?v=1769405407","url":"https:\/\/afsbio.com\/products\/cot-polyclonal-antibody-bt-ap02143","provider":"AFSBio Inc.","version":"1.0","type":"link"}