{"product_id":"coup-tf-ii-polyclonal-antibody-gcp118","title":"COUP-TF II Polyclonal Antibody-GCP118","description":"\u003cp\u003eCOUP-TF II Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: GCP118-50, GCP118-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P24468\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:1000~1:2000\u003cbr\u003e\nIHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes . COUP-TFI and II bind to 5'-AGGTCA-3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP-TFI is involved in neuronal development, tissue patterning, and differentiation . COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: COUP-TF II polyclonal antibody detects endogenous levels of COUP-TF II protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 47 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of COUP-TF II polyclonal antibody at 1:1000 dilution\u003cbr\u003e\n Lane 1: HEK293T whole cell lysate (40ug)\u003cbr\u003e\n Lane 2: A549 whole cell lysate (40ug)\u003cbr\u003e\n Lane 3: HepG2 whole cell lysate (40ug), Immunohistochemistry of paraffin-embedded Rat Brain using COUP-TF II antibody at dilution of 1:50., Western blot (WB) analysis of COUP-TF II polyclonal antibody at 1:1000 dilution\u003cbr\u003e\n Lane 1: A549 whole cell lysate (40ug)\u003cbr\u003e\n Lane 2: COUP-TF II knockdown A549 whole cell lysate (40ug)\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: COUP transcription factor 2; Apolipoprotein A-I regulatory protein 1; COUP transcription factor II; COUP-TF2; Nuclear receptor subfamily 2 group F member 2; ARP-1; COUP-TF II; NR2F2; ARP1; TFCOUP2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human COUP-TF II.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42989605617843,"sku":"GCP118-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42989605650611,"sku":"GCP118-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_555abbb8-04bd-4efb-a19f-6a53ee214029.jpg?v=1706096182","url":"https:\/\/afsbio.com\/products\/coup-tf-ii-polyclonal-antibody-gcp118","provider":"AFSBio Inc.","version":"1.0","type":"link"}