{"product_id":"cox-11-f80-polyclonal-antibody-bs2185","title":"Cox-11 (F80) Polyclonal Antibody-BS2185","description":"\u003cp\u003eCox-11 (F80) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2185-50, BS2185-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9Y6N1\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cytochrome c oxidase (COX) is the terminal enzyme in the electron transfer chain, functioning as a transmembrane proton pump that builds an electrochemical gradient with chemical energy from the reduction of O2. Cytochrome c oxidase assembly protein COX11 is an intracellular mitochondrial membrane protein necessary for the construction of an active COX complex. COX11 contains a single transmembrane helix downstream of the N-terminal, mitochondrial targeting sequence and a C-terminal Cu(I)-binding domain. The assembly of COX requires the delivery of metal cofactors. Along with COX12 and SCO1\/2, COX11 acts as a metal ion chaperone necessary for copper insertion into CuA and CuB redox-active copper centers of COX in eukaryotes.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunohistochemistry (IHC) analyzes of Cox-11 (F80) pAb in paraffin-embedded human tonsil cancer tissue at 1:50.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 31 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Cox-11 (F80) polyclonal antibody detects endogenous levels of Cox-11 protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Cytochrome c oxidase assembly protein COX11, mitochondrial; COX11\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human Cox-11.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939297005747,"sku":"BS2185-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939297038515,"sku":"BS2185-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_c683861a-c033-4000-bf32-3edc577bf905.jpg?v=1704545812","url":"https:\/\/afsbio.com\/products\/cox-11-f80-polyclonal-antibody-bs2185","provider":"AFSBio Inc.","version":"1.0","type":"link"}