{"product_id":"cox1-polyclonal-antibody-bs90325","title":"COX1 Polyclonal Antibody-BS90325","description":"\u003cp\u003eCOX1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90325-50, BS90325-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P23219(Human) P22437(Mouse) Q63921(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC IHC FC IP,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB:1:1,000-1:5,000\u003cbr\u003e\nICC:1:100-1:500\u003cbr\u003e\nIHC:1:50-1:200\u003cbr\u003e\nFC:1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cytochrome c oxidase subunit I, COX1 (also designated COI, MTCO1 or oxidative phosphorylation (OxPhos) Complex IV, subunit I) is one of three mitochondrial DNA (mtDNA) encoded subunits (MTCO1-3) of respiratory Complex IV. Cytochrome c oxidase is a hetero-oligomeric enzyme composed of 13 subunits localized to the mitochondrial inner membrane and is the terminal enzyme complex of the electron transport chain. Complex IV catalyzes the reduction of molecular oxygen to water. The energy released is used to transport protons across the mitochondrial inner membrane. The resulting electro-chemical gradient is necessary for the synthesis of ATP. Complex IV contains 13 polypeptides; COX1, COX2 and COX3 (MTCO1-3) make up the catalytic core and are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc and VIII are nuclear-encoded.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: COX1 polyclonal antibody detects endogenous levels of COX1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 69 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of COX1 on different lysates using anti-COX1 antibody at 1\/1,000 dilution. \u003cbr\u003e\n Positive control:\u003cbr\u003e\n Lane 1: C2C12\u003cbr\u003e\n Lane 2: A431, ICC staining COX1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: COX-1, PGH synthase 1, PGHS-1, PHS 1, PTGS1, COX 1, COX 3, COX-1, COX1, Cox3, Cyclooxygenase 1, Cyclooxygenase 3, included, Cyclooxygenase-1, EC 1.14.99.1, Partial COX1 proteins, included, PCOX1, PGG\/HS, PGH synthase 1, PGH1, PGHS-1, PGHS1, PHS 1, PHS1, Prostaglandin G\/H synthase 1, Prostaglandin H2 synthase 1, Prostaglandin-endoperoxide synthase 1 (prostaglandin G\/H synthase and cyclooxygenase), Prostaglandin-endoperoxide synthase 1, PTGHS, PTGS1,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42979801202867,"sku":"BS90325-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42979801235635,"sku":"BS90325-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_3eef17f0-0824-4022-87c2-263ec192b5bd.jpg?v=1705752831","url":"https:\/\/afsbio.com\/products\/cox1-polyclonal-antibody-bs90325","provider":"AFSBio Inc.","version":"1.0","type":"link"}