{"product_id":"cox10-polyclonal-antibody-bt-ap02147","title":"COX10 Polyclonal Antibody - BT-AP02147","description":"\u003cp\u003eCOX10 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02147-20, BT-AP02147-50, BT-AP02147-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. COX10 encodes heme A: farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. COX10, heme A: farnesyltransferase cytochrome c oxidase assembly factor is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: COX10\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: COX10 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 48882\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q12887; Mouse: Q8CFY5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: COX10; Protoheme IX farnesyltransferase; mitochondrial; Heme O synthase\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1352\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240229331123,"sku":"BT-AP02147-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240229363891,"sku":"BT-AP02147-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240229396659,"sku":"BT-AP02147-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_af7463d5-b071-49af-9827-dfff74bc7452.png?v=1769405412","url":"https:\/\/afsbio.com\/products\/cox10-polyclonal-antibody-bt-ap02147","provider":"AFSBio Inc.","version":"1.0","type":"link"}