{"product_id":"cr1-polyclonal-antibody-ra31810","title":"CR1 Polyclonal Antibody - RA31810","description":"CR1 Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA31810-50, RA31810-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: complement C3b\/C4b receptor 1 (Knops blood group) (CR1) Homo sapiens This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and\/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants\n\nCondition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: WB 1:500-2000 ELISA 1:5000-20000\n\nApplications: WB; ELISA\n\nSpecies Cross-Reactivity: Human; Rat; Mouse\n\nGeneID (Human): 1378\n\nProtein MW (KDa): 224\n\nSWISS: P17927\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45120449085619,"sku":"RA31810-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45120449118387,"sku":"RA31810-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_34249a82-c335-423b-94ed-44c31c986c6c.png?v=1773365738","url":"https:\/\/afsbio.com\/products\/cr1-polyclonal-antibody-ra31810","provider":"AFSBio Inc.","version":"1.0","type":"link"}