{"product_id":"crk-ii-monoclonal-antibody-bt-mca0387","title":"Crk II Monoclonal Antibody - BT-MCA0387","description":"\u003cp\u003eCrk II Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA0387-50, BT-MCA0387-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CRK\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Mouse,Dog,Rabbit\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Adapter molecule crk\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P46108; Mouse: Q64010; Rat: Q63768\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1398; Mouse: 12928\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238685597875,"sku":"BT-MCA0387-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238685630643,"sku":"BT-MCA0387-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_48634193-11c3-448e-a9d3-0d0f04fe2076.png?v=1769383765","url":"https:\/\/afsbio.com\/products\/crk-ii-monoclonal-antibody-bt-mca0387","provider":"AFSBio Inc.","version":"1.0","type":"link"}