{"product_id":"crk-ii-phospho-tyr221-rabbit-pab-es1448","title":"Crk II (phospho Tyr221) rabbit pAb - ES1448","description":"\u003cp\u003eCrk II (phospho Tyr221) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1448-50, ES1448-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat; Monkey\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human CrkII around the phosphorylation site of Tyr221. AA range:187-236\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 40kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 1398\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P46108\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202014568627,"sku":"ES1448-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202014601395,"sku":"ES1448-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_1bdaa7fc-3be8-429b-9f7f-37cdf6d79a7f.png?v=1767119956","url":"https:\/\/afsbio.com\/products\/crk-ii-phospho-tyr221-rabbit-pab-es1448","provider":"AFSBio Inc.","version":"1.0","type":"link"}