{"product_id":"crk-ii-polyclonal-antibody-bt-ap02234","title":"Crk II Polyclonal Antibody - BT-AP02234","description":"\u003cp\u003eCrk II Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02234-20, BT-AP02234-50, BT-AP02234-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CRK encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of CRK has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CRK\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Crk II Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 33872\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P46108; Mouse: Q64010; Rat: Q63768\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1398; Mouse: 12928; Rat: 54245\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240234508467,"sku":"BT-AP02234-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240234541235,"sku":"BT-AP02234-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240234574003,"sku":"BT-AP02234-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d806858d-4c58-4cf5-ac7c-e2010e9a0375.png?v=1769405496","url":"https:\/\/afsbio.com\/products\/crk-ii-polyclonal-antibody-bt-ap02234","provider":"AFSBio Inc.","version":"1.0","type":"link"}