{"product_id":"crk-l-monoclonal-antibody-bt-mca0388","title":"Crk-L Monoclonal Antibody - BT-MCA0388","description":"\u003cp\u003eCrk-L Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA0388-50, BT-MCA0388-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Neuroscience; Signal transduction; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CRKL\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FCM, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Crk-like protein\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P46109; Mouse: P47941\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CRKL; Crk-like protein\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1399\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238685728947,"sku":"BT-MCA0388-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238685761715,"sku":"BT-MCA0388-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_4d33110c-6358-4d88-a4d1-b4f5e7e8e582.png?v=1769383767","url":"https:\/\/afsbio.com\/products\/crk-l-monoclonal-antibody-bt-mca0388","provider":"AFSBio Inc.","version":"1.0","type":"link"}