{"product_id":"crk-l-phospho-tyr207-rabbit-pab-es1517","title":"Crk-L (phospho Tyr207) rabbit pAb - ES1517","description":"\u003cp\u003eCrk-L (phospho Tyr207) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1517-50, ES1517-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: CRKL; Crk-like protein\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat; Monkey\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human CrkL around the phosphorylation site of Tyr207. AA range:173-222\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 39kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 1399\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P46109\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: endosome, cytosol, cell-cell adherens junction, extracellular exosome,\u003c\/p\u003e \n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202020171955,"sku":"ES1517-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202020204723,"sku":"ES1517-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_0ea3bbf2-87c8-4219-8852-1a64caf79cb6.png?v=1767120039","url":"https:\/\/afsbio.com\/products\/crk-l-phospho-tyr207-rabbit-pab-es1517","provider":"AFSBio Inc.","version":"1.0","type":"link"}