{"product_id":"crk-monoclonal-antibody-bt-mca2997","title":"CRK Monoclonal Antibody - BT-MCA2997","description":"\u003cp\u003eCRK Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2997-50, BT-MCA2997-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CRK\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 3G11E8\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CRK\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CRK expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 42kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P46108\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CRKII\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 1398\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238589915315,"sku":"BT-MCA2997-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238589948083,"sku":"BT-MCA2997-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d208e015-e563-4559-b757-4707039f32ca.png?v=1769382857","url":"https:\/\/afsbio.com\/products\/crk-monoclonal-antibody-bt-mca2997","provider":"AFSBio Inc.","version":"1.0","type":"link"}