{"product_id":"crk2-monoclonal-antibody-mb0130","title":"Crk2 Monoclonal Antibody-MB0130","description":"\u003cp\u003eCrk2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB0130-50, MB0130-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P46108\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities. Crk II has less transforming activity than Crk I, although both Crk I and Crk II bind to many tyrosine-phosphorylated proteins that bind to GRB2. In addition, Crk II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) and might be involved in the IGF-I receptor signalling pathway.\u003c\/p\u003e \n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Crk2 mAb detects endogenous levels of Crk2 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Predicted band size:34kDa \u003cbr\u003e\nObserved band size:34kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western BlotDetection of CRK in LNCAP, A431, MCF7\u0026amp;HT1080 cell lysates using CRK antibody (1:1000 diluted).\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Adapter molecule crk; Proto-oncogene c-Crk; p38 CRK; CRK; CRKII\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant full length Human Crk2.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923521736883,"sku":"MB0130-50","price":334.88,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923521769651,"sku":"MB0130-100","price":576.38,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_aa933405-906c-4cac-b4a9-aa1137e5b1ab.jpg?v=1703851082","url":"https:\/\/afsbio.com\/products\/crk2-monoclonal-antibody-mb0130","provider":"AFSBio Inc.","version":"1.0","type":"link"}