{"product_id":"crmp-3-rabbit-pab-es4508","title":"CRMP-3 rabbit pAb - ES4508","description":"\u003cp\u003eCRMP-3 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4508-50, ES4508-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: disease:Antibodies against post-translationally modified DPYSL4, also called anti-CV2 autoantibodies, are present in sera from patients with paraneoplastic neurological diseases (PND). PND are disorders of the nervous system associated with various systemic cancers which are not a direct result of the tumor mass or metastasis, but attributed to remote effects of the cancer., function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the DHOase family. Hydantoinase\/dihydropyrimidinase subfamily., subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: DPYSL4; CRMP3; ULIP4; Dihydropyrimidinase-related protein 4; DRP-4; Collapsin response mediator protein 3; CRMP-3; UNC33-like phosphoprotein 4; ULIP-4\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human DPYSL4. AA range:91-140\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 62kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 10570\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: O14531\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202199806131,"sku":"ES4508-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202199838899,"sku":"ES4508-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_3b513911-6393-459e-a69d-317728fd0852.png?v=1767124086","url":"https:\/\/afsbio.com\/products\/crmp-3-rabbit-pab-es4508","provider":"AFSBio Inc.","version":"1.0","type":"link"}