{"product_id":"crsp77-polyclonal-antibody-bt-ap02253","title":"CRSP77 Polyclonal Antibody - BT-AP02253","description":"\u003cp\u003eCRSP77 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02253-20, BT-AP02253-50, BT-AP02253-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. Mediator complex subunit 17 encoded by MED17 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience; Endocrine system\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MED17\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CRSP77 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 72876\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9NVC6; Mouse: Q8VCD5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: MED17; ARC77; CRSP6; DRIP77; DRIP80; TRAP80; Mediator of RNA polymerase II transcription subunit 17; Activator-recruited cofactor 77 kDa component; ARC77; Cofactor required for Sp1 transcriptional act\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 9440; Mouse: 234959\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240236114099,"sku":"BT-AP02253-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240236146867,"sku":"BT-AP02253-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240236179635,"sku":"BT-AP02253-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d87a5d2b-e87c-4dae-a445-f0d7d30dd0c8.png?v=1769405514","url":"https:\/\/afsbio.com\/products\/crsp77-polyclonal-antibody-bt-ap02253","provider":"AFSBio Inc.","version":"1.0","type":"link"}