{"product_id":"crtc3-monoclonal-antibody-bt-mca4191","title":"CRTC3 Monoclonal Antibody - BT-MCA4191","description":"\u003cp\u003eCRTC3 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4191-50, BT-MCA4191-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK\/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling, Microbiology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CRTC3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, ICC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5G9\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CRTC3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CRTC3 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 68kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q6UUV7\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TORC3, FLJ21868, CRTC3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 64784\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238606528691,"sku":"BT-MCA4191-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238606561459,"sku":"BT-MCA4191-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_32abf260-ec2a-48ce-83be-5aac5025efce.png?v=1769383000","url":"https:\/\/afsbio.com\/products\/crtc3-monoclonal-antibody-bt-mca4191","provider":"AFSBio Inc.","version":"1.0","type":"link"}