{"product_id":"cryopyrin-polyclonal-antibody-ra21340","title":"Cryopyrin Polyclonal Antibody - RA21340","description":"Cryopyrin Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA21340-50, RA21340-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: NLR family pyrin domain containing 3 (NLRP3) Homo sapiens This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD\/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID) . Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are s\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. IHC-p: 1\/100-1\/300. ELISA: 1\/20000. Not yet tested in other applications.\n\nAlternative Names: NLRP3; C1orf7; CIAS1; NALP3; PYPAF1; NACHT, LRR and PYD domains-containing protein 3; Angiotensin\/vasopressin receptor AII\/AVP-like; Caterpiller protein 1.1CLR1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1\n\nApplications: WB; IHC-p; IF (paraffin section) ; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 114548\n\nProtein MW (KDa): 115\n\nSWISS: Q96P20\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121060077747,"sku":"RA21340-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121060110515,"sku":"RA21340-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ee22bfc6-712a-46fc-840d-62c67484d230.png?v=1773370206","url":"https:\/\/afsbio.com\/products\/cryopyrin-polyclonal-antibody-ra21340","provider":"AFSBio Inc.","version":"1.0","type":"link"}