{"product_id":"csk-monoclonal-antibody-bt-mca4035","title":"CSK Monoclonal Antibody - BT-MCA4035","description":"\u003cp\u003eCSK Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4035-50, BT-MCA4035-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CSK\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Monkey, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5F3\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CSK\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CSK expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 50kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P41240\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: MGC117393, CSK\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 1445\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238611411123,"sku":"BT-MCA4035-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238611443891,"sku":"BT-MCA4035-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_cd890532-0504-4003-b864-12b96564933c.png?v=1769383059","url":"https:\/\/afsbio.com\/products\/csk-monoclonal-antibody-bt-mca4035","provider":"AFSBio Inc.","version":"1.0","type":"link"}