{"product_id":"ctnnb1-monoclonal-antibody-bt-mca3475","title":"CTNNB1 Monoclonal Antibody - BT-MCA3475","description":"\u003cp\u003eCTNNB1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3475-50, BT-MCA3475-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CTNNB1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5B6E9\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CTNNB1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CTNNB1 (AA: 632-781) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 85.5kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P35222\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CTNNB, MRD19, armadillo\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 1499\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238396289203,"sku":"BT-MCA3475-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238396321971,"sku":"BT-MCA3475-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ff920c20-22e0-461b-906d-7e823b82d939.png?v=1769379909","url":"https:\/\/afsbio.com\/products\/ctnnb1-monoclonal-antibody-bt-mca3475","provider":"AFSBio Inc.","version":"1.0","type":"link"}