{"product_id":"cullin-5-monoclonal-antibody-mb10782","title":"Cullin 5 Monoclonal Antibody-MB10782","description":"\u003cp\u003eCullin 5 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB10782-50, MB10782-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q93034\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000\u003c\/p\u003e  \n\n\u003cp\u003eBackground: Core component of multiple SCF-like ECS (Elongin-Cullin 2\/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53\/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Cullin 5\/CUL5 in C6, 3T3, HelaLysates using Cullin 5 antibody.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 91 kDa; Observed MW: 91 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CUL-5; VACM1; VACM-1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human Cullin 5\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42935446405299,"sku":"MB10782-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42935446438067,"sku":"MB10782-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_271812ac-ab5a-43f5-91ea-f909a3e9f098.jpg?v=1704370894","url":"https:\/\/afsbio.com\/products\/cullin-5-monoclonal-antibody-mb10782","provider":"AFSBio Inc.","version":"1.0","type":"link"}