{"product_id":"cxcr-3-rabbit-pab-es4007","title":"CXCR-3 rabbit pAb - ES4007","description":"\u003cp\u003eCXCR-3 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4007-50, ES4007-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: C-X-C motif chemokine receptor 3 (CXCR3) Homo sapiens This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9\/Mig (monokine induced by interferon-g), CXCL10\/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11\/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4\/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: CXCR3; GPR9; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD183\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. IHC-p: 1:100-300 ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse; Pig; Chicken\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CXCR3. AA range:161-210\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 37kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 2833\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P49682\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Isoform 1]: Cell membrane; Multi-pass membrane protein.; [Isoform 2]: Cell membrane; Multi-pass membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202169233587,"sku":"ES4007-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202169266355,"sku":"ES4007-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_a2f2eb76-eb09-4b6f-8ada-5a6fb05f41dd.png?v=1767123501","url":"https:\/\/afsbio.com\/products\/cxcr-3-rabbit-pab-es4007","provider":"AFSBio Inc.","version":"1.0","type":"link"}