{"product_id":"cxxc4-rabbit-polyclonal-antibody-ra23913","title":"CXXC4 Rabbit Polyclonal Antibody - RA23913","description":"\u003cp\u003eCXXC4 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA23913-50, RA23913-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless\/integrated signaling pathway. The encoded protein negatively regulates wingless\/integrated signaling through interaction with the post synaptic density protein\/ Drosophila disc large tumor suppressor\/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 80319\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9H2H0\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119505236147,"sku":"RA23913-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119505268915,"sku":"RA23913-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1aa6f65e-fb3a-4ea6-a1c5-7bafd3e1cbe0.png?v=1773354571","url":"https:\/\/afsbio.com\/products\/cxxc4-rabbit-polyclonal-antibody-ra23913","provider":"AFSBio Inc.","version":"1.0","type":"link"}