{"product_id":"cyclin-d1-monoclonal-antibody-bs65502","title":"Cyclin D1 Monoclonal Antibody-BS65502","description":"\u003cp\u003eCyclin D1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65502-50, BS65502-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P25322\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-P\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB=1:500-2000 IHC-P=1:50-200\u003cbr\u003e\nnot yet tested in other applications.\u003cbr\u003e\noptimal dilutions\/concentrations should be determined by the end user.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1\/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Cyclin D1 monoclonal Antibody detects endogenous levels of Cyclin D1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~34 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Cyclin D1 monoclonal antibody at 1:1000 dilution., Immunohistochemistry of paraffin-embedded human tonsil damage using Cyclin D1 monoclonal antibody at dilution of 1:200.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CyclinD1; Cyclin-D1; B cell ccl\/lymphoma 1; B cell leukemia 1; B-cell CLL\/lymphoma 1; B-cell leukemia 1; B-cell lymphoma 1 protein; BCL-1; BCL1; BCL1 oncogene; CCND 1; CCND1; CCND1 protein; CCND1\/FSTL3 fusion gene, included; CCND1\/IGHG1 fusion gene; CCND1\/IGHG1 fusion gene, included; CCND1\/IGLC1 fusion gene, included; CCND1\/PTH fusion gene, included; Parathyroid adenomatosis 1; PRAD1; FSTL3; CCND1_HUMAN; AI327039; B cell lymphoma 1 protein; BCL 1; BCL-1; BCL-1 oncogene; BCL1 oncogene; CCND1\/FSTL3 fusion gene, included; cD1; Cyl 1; D11S287E; G1\/S specific cyclin D1; G1\/S-specific cyclin-D1.\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant human Cyclin D1 protein, around C-terminal 150aa:\u003c\/p\u003e \n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42987085594803,"sku":"BS65502-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42987085627571,"sku":"BS65502-100","price":919.06,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_6609dae3-5da0-4ac4-bcdf-15b1a7efd434.jpg?v=1706008825","url":"https:\/\/afsbio.com\/products\/cyclin-d1-monoclonal-antibody-bs65502","provider":"AFSBio Inc.","version":"1.0","type":"link"}