{"product_id":"cyclin-d1-phospho-ser90-rabbit-pab-es20156","title":"Cyclin D1 (Phospho Ser90) rabbit pAb - ES20156","description":"\u003cp\u003eCyclin D1 (Phospho Ser90) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20156-50, ES20156-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t (11; 14) (q13; q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle., disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t (11; 14) (q13; q32) with the IgH locus., disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t (11; 11) (q13; p15) with the parathyroid hormone (PTH) enhancer., function:Essential for the control of the cell cycle at the G1\/S (start) transition., online information:The Singapore human mutation and polymorphism database, PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest., PTM:Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex., similarity:Belongs to the cyclin family., similarity:Belongs to the cyclin family. Cyclin D subfamily., subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine\/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: G1\/S-specific cyclin-D1 (B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human Cyclin D1 (Phospho Ser90)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 33kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 595\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P24385\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Cytoplasm. Nucleus membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP\/CIP family members.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202428035251,"sku":"ES20156-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202428068019,"sku":"ES20156-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_1c1564c8-6ff5-4d61-a379-a1c28e4e2d0a.png?v=1767128992","url":"https:\/\/afsbio.com\/products\/cyclin-d1-phospho-ser90-rabbit-pab-es20156","provider":"AFSBio Inc.","version":"1.0","type":"link"}