{"product_id":"cyclin-d1-phospho-ser90-rabbit-polyclonal-antibody-ra23929","title":"Cyclin D1 (Phospho Ser90) Rabbit Polyclonal Antibody - RA23929","description":"\u003cp\u003eCyclin D1 (Phospho Ser90) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA23929-50, RA23929-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL) . Translocation t (11;14) (q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.,disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t (11;14) (q13;q32) with the IgH locus.,disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t (11;11) (q13;p15) with the parathyroid hormone (PTH) enhancer.,function:Essential for the control of the cell cycle at the G1\/S (start) transition.,online information:The Singapore human mutation and polymorphism database,PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest.,PTM:Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin D subfamily.,subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine\/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.,\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:1000-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: G1\/S-specific cyclin-D1 (B-cell lymphoma 1 protein;BCL-1;BCL-1 oncogene;PRAD1 oncogene)\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 595\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 130\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P24385\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121225556147,"sku":"RA23929-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121225588915,"sku":"RA23929-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5fe182f2-35ed-4e56-99c9-393523fa63b6.png?v=1773345433","url":"https:\/\/afsbio.com\/products\/cyclin-d1-phospho-ser90-rabbit-polyclonal-antibody-ra23929","provider":"AFSBio Inc.","version":"1.0","type":"link"}